Article

Transposable element RNA dysregulation in mutant KRAS(G12C) 3D lung cancer spheroids

2023-02-28

Abstract excerpt

<h4>ABSTRACT</h4> Mutant KRAS regulates transposable element (TE) RNA and interferon-stimulated gene (ISG) expression, but it remains unclear whether diverse mutations in KRAS affect different TE RNAs throughout the genome. We analyzed the transcriptomes of 3D human lung cancer spheroids that harbor KRAS(G12C) mutations to determine the landscape of TE RNAs regulated by mutant KRAS(G12C). We found that KRAS(G12C)...

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Literature Corpus work: ca26b961-4609-59ea-a173-62aeaf2f30f5
DOI: 10.1101/2023.02.27.530369

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