Article

CasRx-Based Kras G12D Silencing for In Vivo Tumor Inhibition in Spontaneous Lung Adenocarcinoma

2024-03-15

Abstract excerpt

<title>Abstract</title> <p>KRAS mutation represents a formidable challenge in cancer treatment. Here, we explored the CasRx-editing approach on lung adenocarcinoma driven by KRAS activation and Tp53 loss in vivo, a scenario closely resembling clinical conditions. We screened seven sgRNAs in vitro and identified CasRx + sgRNA5 effectively suppressed Kras-G12D transcript levels, leading to attenuation of cell growt...

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Literature Corpus work: 96187981-6a6d-52ad-9c91-cf96c014d9e3
DOI: 10.21203/rs.3.rs-4041534/v1

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