Article
Mutant KRAS regulates transposable element RNA and innate immunity via KRAB zinc-finger genes.
Cell reports - 19 Jul 2022
Reggiardo Roman E, Maroli Sreelakshmi Velandi, Halasz Haley, Ozen Mehmet, Hrabeta-Robinson Eva, Behera Amit, Peddu Vikas, Carrillo David, LaMontagne Erin, Whitehead Lila, Kim Eejung, Malik Shivani, Fernandes Jason, Marinov Georgi, Collisson Eric, Brooks Angela, Demirci Utkan, Kim Daniel H
Abstract excerpt
RAS genes are the most frequently mutated oncogenes in cancer, yet the effects of oncogenic RAS signaling on the noncoding transcriptome remain unclear. We analyzed the transcriptomes of human airway and bronchial epithelial cells transformed with mutant KRAS to define the landscape of KRAS-regulated noncoding RNAs. We find that oncogenic KRAS signaling upregulates noncoding transcripts throughout the genome,...
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