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Article

Epigenomic reprogramming of repetitive noncoding RNAs and IFN-stimulated genes by mutant KRAS

2020-11-04

Abstract excerpt

<h4>ABSTRACT</h4> RAS genes are the most frequently mutated oncogenes in cancer. However, the effects of oncogenic RAS signaling on the noncoding transcriptome are unclear. We analyzed the transcriptomes of human airway epithelial cells transformed with mutant KRAS to define the landscape of KRAS-regulated noncoding RNAs. We found that oncogenic KRAS upregulates noncoding transcripts throughout the genome, many o...

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Literature Corpus work
c7f3eaa1-7462-518f-a623-4798727a52a2
DOI
10.1101/2020.11.04.367771
Open publication

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Epigenomic reprogramming of repetitive noncoding RNAs and IFN-stimulated genes by mutant KRASDOI 10.1101/2020.11.04.367771
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