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Article

Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models.

Cell research - 1 Dec 2017

Yu Meng, Fu Yuhua, Liang Yijiang, Song Haikun, Yao Yao, Wu Peng, Yao Yuwei, Pan Yuyin, Wen Xue, Ma Lixiang, Hexige Saiyin, Ding Yu, Luo Shouqing, Lu Boxun

Abstract excerpt

Most neurodegenerative disorders are associated with accumulation of disease-relevant proteins. Among them, Huntington disease (HD) is of particular interest because of its monogenetic nature. HD is mainly caused by cytotoxicity of the defective protein encoded by the mutant Huntingtin gene (HTT). Thus, lowering mutant HTT protein (mHTT) levels would be a promising treatment strategy for HD. Here we report two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29151587
DOI: 10.1038/cr.2017.113
PMCID: PMC5717400

Genes

HTT
MAPK11
HIPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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