Article

Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening

2024-02-02

Abstract excerpt

<title>Abstract</title> Background Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis. Current treatment options are limited and often ineffective. CAR T cell therapy has shown success in treating hematologic malignancies, and there is growing interest in its potential application in solid tumors, including GBM. However, current CAR T therapy lacks clinical efficacy against...

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Literature Corpus work: ca20dcd3-6bf4-5de6-98c6-cf232594f605
DOI: 10.21203/rs.3.rs-3878400/v1

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