Article

Targeting a check point receptor of human primary natural killer cells via CRISPR/Cas9 potentiates anti-tumor activity in allogeneic glioblastoma

2023-01-30

Abstract excerpt

<h4>Background: </h4> Patients with glioblastoma (GBM) have poor outcomes and novel strategies are needed. Although immunotherapies have been investigated, altering the severe immunosuppressive tumor microenvironment, or so-called “cold tumors”, is difficult. We developed an immunotherapy based on genome-edited natural killer cells (NKCs) with knocking (KO) of checkpoint receptor T-cell immunoglobulin and immunore...

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Literature Corpus work: dacc2408-74e6-5eb0-97d4-f5459b48db09
DOI: 10.21203/rs.3.rs-2518848/v1

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