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Article

Tumour microenvironment programming by an RNA-RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma.

Nature cell biology - 1 Jun 2024

Wu Lele, Zhao Zheng, Shin Yong Jae, Yin Yiyun, Raju Anandhkumar, Vaiyapuri Thamil Selvan, Idzham Khaireen, Son Miseol, Lee Yeri, Sa Jason K, Chua Joelle Yi Heng, Unal Bilal, Zhai You, Fan Wenhua, Huang Lijie, Hu Huimin, Gunaratne Jayantha, Nam Do-Hyun, Jiang Tao, Tergaonkar Vinay

Abstract excerpt

Patients with IDH-wild-type glioblastomas have a poor five-year survival rate along with limited treatment efficacy due to immune cell (glioma-associated microglia and macrophages) infiltration promoting tumour growth and resistance. To enhance therapeutic options, our study investigated the unique RNA-RNA-binding protein complex LOC-DHX15. This complex plays a crucial role in driving immune cell infiltration and...

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Source

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Identifiers

PMID: 38858501
DOI: 10.1038/s41556-024-01428-5
PMCID: PMC11178504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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