Article

Evolutionary diversity of CXCL16 <i>-</i> CXCR6: Convergent Substitutions and Recurrent Gene Loss in Sauropsids

2024-09-24

Abstract excerpt

The CXCL16-CXCR6 axis is crucial for regulating the persistence of CD8 tissue-resident memory T-cells (T RM ). CXCR6 deficiency lowers T RM cell numbers in the lungs and depletes ILC3s in the lamina propria, impairing mucosal defence. This axis is linked to diseases like HIV/SIV, cancer, and COVID-19. Together, these highlight that the CXCL16-CXCR6 axis is pivotal in host immunity. Previous studies of the CXCL16...

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Literature Corpus work: ca177a49-2c40-513f-a55d-11786f6edda9
DOI: 10.1101/2024.09.20.614078

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