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Evolutionary diversity of CXCL16-CXCR6: Convergent substitutions and recurrent gene loss in sauropsids.

Immunogenetics - 1 Dec 2024

Salve Buddhabhushan Girish, Sharma Sandhya, Vijay Nagarjun

Abstract excerpt

The CXCL16-CXCR6 axis is crucial for regulating the persistence of CD8 tissue-resident memory T cells (TRM). CXCR6 deficiency lowers TRM cell numbers in the lungs and depletes ILC3s in the lamina propria, impairing mucosal defence. This axis is linked to diseases like HIV/SIV, cancer, and COVID-19. Together, these highlight that the CXCL16-CXCR6 axis is pivotal in host immunity. Previous studies of the...

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PMID: 39400711
DOI: 10.1007/s00251-024-01357-5

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