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Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history

12 Nov 2012

Abstract excerpt

The genes involved in host defences are known to undergo rapid evolution. Therefore, it is often difficult to assign orthologs in multigene families among various vertebrate species. Chemokines are a large family of small cytokines that orchestrate cell migration in health and disease. Herein, we have surveyed the genomes of 18 representative vertebrate species for chemokine genes and identified a total of 553...

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PMID: 23145839
DOI: 10.1111/gtc.12013

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