Article

Endocytic CEACAM receptor loss and lack of positive selection in CEACAM1 of birds and snakes indicate absence of pathogen-CEACAM1 interactions in some reptiles

2026-06-11

Abstract excerpt

<title>Abstract</title> <p>The CEACAM gene family is among the fastest evolving in vertebrates. It likely originated from an ancestral CEACAM1-like gene encoding an inhibitory receptor. In mammals, CEACAM1 is expressed on epithelial cells and can regulate leukocyte activation. Thus, several bacterial pathogens exploit it for host entry and immune suppression. Probably this threat selected for the evolution of dec...

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Literature Corpus work: 084fa311-add4-55eb-815c-2ebe3522954f
DOI: 10.21203/rs.3.rs-9693666/v1

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Endocytic CEACAM receptor loss and lack of positive selection in CEACAM1 of birds and snakes indicate absence of pathogen-CEACAM1 interactions in some reptilesDOI 10.21203/rs.3.rs-9693666/v1Read

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