Article
Resetting proteostasis with ISRIB prevents pulmonary fibrosis
2020-02-27
Abstract excerpt
Aging is among the most important risk factors for the development of pulmonary fibrosis. We found that a small molecule that specifically inhibits translational inhibition induced by activation of the integrated stress response (ISRIB) attenuated the severity of pulmonary fibrosis in young and old mice. The more severe fibrosis in old compared to young mice was associated with increased recruitment of pathogenic...
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Identifiers and source
- Literature Corpus work
- ca011b3b-72ef-5e95-afa7-df1b54024f1c
- DOI
- 10.1101/2020.02.26.965566