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Identification of replicative aging and inflammatory aging signatures via whole-genome CRISPRi screens

6 Aug 2025

Abstract excerpt

BACKGROUND: Aging is a major risk factor for chronic diseases and cancer. Cellular aging, particularly in adult stem cells, offers a high-throughput framework for dissecting the molecular mechanisms of aging. RESULTS: We perform multiple genome-wide CRISPR interference (CRISPRi) screenings in human primary mesenchymal stem cells derived from adipose tissue during either replicative senescence or...

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PMID: 40770768
DOI: 10.1186/s13059-025-03683-7

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