Article

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis

2021-09-17

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a disease of progressive interstitial fibrosis, which leads to severe debilitation, respiratory failure, and death. In IPF, environmental exposures interact with genetic risk factors to engender critical patho-etiological events in lung epithelial cells, including endoplasmic reticulum (ER) stress and TGFβ signaling, but the interactions between these disparate pathways are n...

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Literature Corpus work: f56b8c9c-c234-5c14-afc6-3c3072066d0b
DOI: 10.1101/2021.09.16.460705

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