Article
A proteomic atlas of senescence-associated secretomes for aging biomarker development.
PLoS biology - 1 Jan 2020
Basisty Nathan, Kale Abhijit, Jeon Ok Hee, Kuehnemann Chisaka, Payne Therese, Rao Chirag, Holtz Anja, Shah Samah, Sharma Vagisha, Ferrucci Luigi, Campisi Judith, Schilling Birgit
Abstract excerpt
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically assessed by a few dozen secreted proteins, has been greatly underestimated, and a small set of factors cannot explain the diverse phenotypes it produces in vivo. Here, we...
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