Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translation is an emerging constraint on protein homeostasis in ageing

28 Feb 2024

Abstract excerpt

Proteins are molecular machines that provide structure and perform vital transport, signalling and enzymatic roles. Proteins expressed by cells require tight regulation of their concentration, folding, localisation, and modifications; however, this state of protein homeostasis is continuously perturbed by tissue-level stresses. While cells in healthy tissues are able to buffer against these perturbations, for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Endoplasmic Reticulum Stress and Disease
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38423854
DOI: 10.1016/j.tcb.2024.02.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translation is an emerging constraint on protein homeostasis in ageingPMID 38423854Read ↗

Cellular proteostasis decline in human senescenceSemantic proximity Read ↗

Dysregulated RNA processing and metabolism: a new hallmark of ageing and provocation for cellular senescenceSemantic proximity Read ↗

Declining intracellular proteostasis capacity drives misfolded protein secretion in senescent human cellsSemantic proximity Read ↗

Cellular proteostasis decline in human senescenceSemantic proximity Read ↗

Crosstalk between protein misfolding and endoplasmic reticulum stress during ageing and their role in age-related disordersSemantic proximity Read ↗

ER-stress signaling and Alzheimer’s proteins adjust the quality of human protein synthesisSemantic proximity Read ↗

Control of mRNA Translation in ALS ProteinopathySemantic proximity Read ↗

Proteostasis Dysfunction in Aged Mammalian Cells. The Stressful Role of InflammationSemantic proximity Read ↗

Senescence suppresses the integrated stress response and activates a stress-enhanced secretory phenotypeSemantic proximity Read ↗

Ribosome biogenesis and homeostasis: in the front line to cope with cellular stressSemantic proximity Read ↗

The Molecular Floodgates of Stress-Induced Senescence Reveal Translation, Signalling and Protein Activity Central to the Post-Mortem Proteome.Semantic proximity Read ↗

MicroRNAs as Mediators of the Ageing ProcessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.