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Article

Development of a Novel Virus-Like Particle Vaccine Platform That Mimics the Immature Form of Alphavirus

18 May 2017

Abstract excerpt

ABSTRACT Virus-like particles (VLPs) are noninfectious multiprotein structures that are engineered to self-assemble from viral structural proteins. Here, we developed a novel VLP-based vaccine platform utilizing VLPs from the chikungunya virus. We identified two regions within the envelope protein, a structural component of chikungunya, where foreign antigens can be inserted without compromising VLP structure....

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PMID: 28515133
DOI: 10.1128/cvi.00090-17

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