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Protein structure shapes immunodominance in the CD4 T cell response to yellow fever vaccination

15 Aug 2017

Abstract excerpt

The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles internalized and processed by E-specific B cells. The CD4 T helper cell response is restricted to...

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PMID: 28827760
DOI: 10.1038/s41598-017-09331-w

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