Back to search

Article

Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone <i>Hsc70-5/mortalin</i> in <i>Drosophila</i>

2020-09-19

Abstract excerpt

We investigate in larval and adult Drosophila models whether loss of the mitochondrial chaperone Hsc70-5 / mortalin is sufficient to cause pathological alterations commonly observed in Parkinson disease. At affected larval neuromuscular junctions, no effects on terminal size, bouton size or number, synapse size, or number were observed, suggesting that we study an early stage of pathogenesis. At this stage, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b5c32f1c-0f66-53c1-9ceb-93183130d8f8
DOI
10.1101/2020.09.17.302141
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone <i>Hsc70-5/mortalin</i> in <i>Drosophila</i>DOI 10.1101/2020.09.17.302141
Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model.Semantic proximity
Insights into Dentatorubral-Pallidoluysian Atrophy from a new <i>Drosophila</i> model of diseaseSemantic proximity
A <i>dwdr45</i> knock-out <i>Drosophila</i> model to decipher the role of autophagy in BPANSemantic proximity
A <i>Drosophila</i> model of mitochondrial disease phenotypic heterogeneitySemantic proximity
Juvenile and adult expression of polyglutamine expanded <i>huntingtin</i> produce distinct aggregate distributions in <i>Drosophila</i> muscleSemantic proximity
Insights into dentatorubral-pallidoluysian atrophy from a new Drosophila model of diseaseSemantic proximity
Behavioral screening defines three molecular Parkinsonism subgroups in <i>Drosophila</i>Semantic proximity
Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency.Semantic proximity
Mutation in <i>Wdr45</i> leads to early motor dysfunction and widespread aberrant axon terminals in a beta-propeller protein associated neurodegeneration (BPAN) patient-inspired mouse modelSemantic proximity
A dwdr45 knock-out drosophila model to decipher the role of autophagy in BPAN.Semantic proximity
Mitochondrial Complex I and ROS control neuromuscular function through opposing pre- and postsynaptic mechanismsSemantic proximity
Mitochondrial fission, integrity and completion of mitophagy require separable functions of Vps13D in <i>Drosophila</i> neuronsSemantic proximity
Select a neighboring publication to make it the new centre.