Article

Epigenetic suppression of interferon lambda receptor expression leads to enhanced HuNoV replication in vitro

2019-01-17

Abstract excerpt

Human norovirus (HuNoV) is the main cause of gastroenteritis worldwide yet no therapeutics are currently available. Here, we utilize a human norovirus replicon in human gastric tumor (HGT) cells to identify host factors involved in promoting or inhibiting HuNoV replication. We observed that an IFN-cured population of replicon-harboring HGT cells (HGT-cured) was enhanced in their ability to replicate transfected Hu...

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Literature Corpus work: c99497ea-9b1a-52ae-b7c8-77dc9c627e3e
DOI: 10.1101/523282

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