Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro.

Antimicrobial agents and chemotherapy - 1 May 2018

Kitano Mitsutaka, Hosmillo Myra, Emmott Edward, Lu Jia, Goodfellow Ian

Abstract excerpt

Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds and has thus accelerated the process of drug discovery against HuNoV infection. Rupintrivir, an irreversible inhibitor of the human rhinovirus 3C protease, has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine Endopeptidases
Share to Fluorescence Resonance Energy Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoxazoles

Share to Phenylalanine

Share to Pyrrolidinones

Share to Valine

Share to Viral Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 29530860
DOI: 10.1128/AAC.00201-18
PMCID: PMC5923142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro.PMID 29530860Read ↗

The Enterovirus Protease Inhibitor Rupintrivir Exerts Cross-Genotypic Anti-Norovirus Activity and Clears Cells from the Norovirus RepliconSemantic proximity Read ↗

A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo.Semantic proximity Read ↗

In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease.Semantic proximity Read ↗

Advanced simulations and screening to design a 3C protease inhibitor against the drug resistant human norovirus-induced gastroenteritisSemantic proximity Read ↗

Advances Toward a Norovirus Antiviral: From Classical Inhibitors to Lethal MutagenesisSemantic proximity Read ↗

Multiple Classes of Antiviral Agents Exhibit In Vitro Activity against Human Rhinovirus Type CSemantic proximity Read ↗

Norovirus: targets and tools in antiviral drug discovery.Semantic proximity Read ↗

The human rhinovirus: human‐pathological impact, mechanisms of antirhinoviral agents, and strategies for their discoverySemantic proximity Read ↗

Replication and Inhibitors of Enteroviruses and ParechovirusesSemantic proximity Read ↗

Antiviral Activity of Nucleoside Analogues against NorovirusSemantic proximity Read ↗

Nonnucleoside inhibitors of norovirus RNA polymerase: scaffolds for rational drug design.Semantic proximity Read ↗

Selective human enterovirus and rhinovirus inhibitors: An overview of capsid‐binding and protease‐inhibiting moleculesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.