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Article

Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids

9 Sept 2020

Abstract excerpt

Significance Host innate immune responses are the first line of defense against viral infections, with the outcome of infection determined by the interplay between virus and host defense mechanisms. We report transcriptomic and functional analyses of epithelial cell responses to HuNoV infection in HIE cultures. HuNoV infection triggers predominantly a type III interferon (IFN) response and upregulation of long...

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PMID: 32907944
DOI: 10.1073/pnas.2010834117

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