Article

Norovirus replication in human intestinal epithelial cells is restricted by the interferon-induced JAK/STAT signalling pathway <i>and</i> RNA Polymerase II mediated transcriptional responses

2019-08-10

Abstract excerpt

Human noroviruses (HuNoV) are a leading cause of viral gastroenteritis worldwide and a significant cause of morbidity and mortality in all age groups. The recent finding that HuNoV can be propagated in B cells and mucosa derived intestinal epithelial organoids (IEOs), has transformed our capability to dissect the life cycle of noroviruses. Using RNA-Seq of HuNoV infected intestinal epithelial cells (IECs), we have...

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Literature Corpus work: 072dbe64-fc53-5dae-b84e-c913de525af6
DOI: 10.1101/731802

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