Article
UHRF1 suppresses viral mimicry through both DNA methylation-dependent and -independent mechanisms
2020-08-31
Abstract excerpt
Some chemotherapeutic agents which cause loss of DNA methylation have been recently shown to induce a state of “viral mimicry” involving upregulation of endogenous retroviruses (ERV) and a subsequent innate immune response. This approach may be useful in combination with immune checkpoint cancer therapies, but relatively little is known about normal cellular control of ERV suppression. The UHRF1 protein can intera...
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Identifiers and source
- Literature Corpus work
- 52302f4a-b358-56dc-8d2f-987d89dee005
- DOI
- 10.1101/2020.08.31.274894