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Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target

2025-09-11

Abstract excerpt

<title>Abstract</title> <p>Mutant isocitrate dehydrogenase 1 (mIDH1) catalyzes 2-hydroxyglutarate production which leads to epigenetic reprogramming. RNA-seq, scRNA-seq, and ChIP-seq analysis revealed that human and mouse mIDH1 gliomas exhibit downregulated gene ontologies (GOs) related to mitochondrial metabolism and upregulated autophagy-related GOs. Decreased mitochondrial metabolism was accompanied by decreas...

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Literature Corpus work
e5fdd4f9-9223-554c-8b45-4eab3f769632
DOI
10.21203/rs.3.rs-7483444/v1
Open publication

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