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Article

Autophagy inhibition sensitizes radiotherapy responses in high-grade mutant IDH1 glioma.

Nature communications - 18 Sept 2026

Núñez Felipe J, Banerjee Kaushik, Mujeeb Anzar A, Mauser Ava, Tronrud Claire E, Zhu Ziwen, Raghuram Sadhakshi, Sheth Maya R, Pena Agudelo Jorge Armando, Zelaya Julio, Taher Ayman, Kadiyala Padma, Carney Stephen V, Garcia-Fabiani Maria B, Comba Andrea, Alghamri Mahmoud S, McClellan Brandon L, Klaiss Adam, Nwosu Zeribe C, Hong Hanna S, Sajjakulnukit Peter, Qin Tingting, Sartor Maureen A, Ljungman Mats, Welch Joshua D, Cheng Shi-Yuan, Lowenstein Pedro R, Lahann Joerg, Lyssiotis Costas A, Castro Maria G

Abstract excerpt

Mutant isocitrate dehydrogenase 1 (mIDH1) catalyzes 2-hydroxyglutarate (2HG) production which leads to epigenetic reprogramming in astrocytomas with tumor protein p53 (TP53)/α-thalassemia/mental retardation, X-linked (ATRX) loss. RNA-sequencing, single-cell RNA-sequencing, and Chromatin Immunoprecipitation sequencing (ChIP-seq) followed by bioinformatics analysis shows that human and mouse mIDH1 gliomas exhibit...

Read the complete abstract on PubMed

Topics

Humans
Isocitrate Dehydrogenase
Autophagy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals

Glioma

Cell Line, Tumor

Mice

Brain Neoplasms

Mutation

Autophagy-Related Protein 7

Radiation Tolerance

Gene Expression Regulation, Neoplastic

Mitochondria

Microtubule-Associated Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42760279
DOI: 10.1038/s41467-026-77320-7
PMCID: PMC13588786

Genes

IDH1
ATG7
ATRX
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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