Article

The mechanochemical origins of the microtubule sliding motility within the kinesin-5 domain organization

2021-10-13

Abstract excerpt

The conserved kinesin-5 bipolar tetrameric motors slide apart microtubules during mitotic spindle assembly and elongation. Kinesin-5 bipolar organization originates from its conserved tetrameric helical minifilament, which position the C-terminal tail domains of two subunits near the N-terminal motor domains of two anti-parallel subunits (Scholey et al, 2014). This unique tetrameric structure enables kinesin-5 to...

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Literature Corpus work: 2b7c9599-30bb-5321-ba34-da05ac9a7e41
DOI: 10.1101/2021.10.12.463902

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