Article
Modular aspects of kinesin force generation machinery.
Biophysical journal - 7 May 2013
Hesse William R, Steiner Miriam, Wohlever Matthew L, Kamm Roger D, Hwang Wonmuk, Lang Matthew J
Abstract excerpt
The motor head of kinesin carries out microtubule binding, ATP hydrolysis, and force generation. Despite a high level of sequence and structural conservation, subtle variations in subdomains of the motor head determine family-specific properties. In particular, both Kinesin-1 (Kin-1) and Kinesin-5 (Kin-5) walk processively to the microtubule plus-end, yet show distinct motility characteristics suitable for their...
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