Back to search

Article

Intracellular injection of brain extracts from Alzheimer’s disease patients trigger unregulated Ca <sup>2+</sup> release from intracellular stores that hinders cellular bioenergetics

2022-04-30

Abstract excerpt

Strong evidence indicates that amyloid beta (Aβ) inflicts its toxicity in Alzheimer’s disease (AD) by promoting uncontrolled elevation of cytosolic Ca 2+ in neurons. We have previously shown that synthetic Aβ42 oligomers stimulate abnormal intracellular Ca 2+ release from the endoplasmic reticulum stores, suggesting that a similar mechanism of Ca 2+ toxicity may be common to the endogenous Aβs oligomers. To inv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c9532cef-252d-5620-94db-32f817babb14
DOI
10.1101/2022.04.29.490088
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Intracellular injection of brain extracts from Alzheimer’s disease patients trigger unregulated Ca <sup>2+</sup> release from intracellular stores that hinders cellular bioenergeticsDOI 10.1101/2022.04.29.490088
Calcium dysregulation, IP3 signaling, and Alzheimer's disease.Semantic proximity
Intracellular calcium signalling in Alzheimer’s diseaseSemantic proximity
Intracellular A? and its Pathological Role in Alzheimer's Disease: Lessons from Cellular to Animal ModelsSemantic proximity
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain.Semantic proximity
Dysregulation of Intracellular Calcium Signaling in Alzheimer's DiseaseSemantic proximity
Amyloid β-Oligomers Inhibit the Nuclear Ca<sup>2+</sup> Signals and the Neuroprotective Gene Expression Induced by Hippocampal Neuronal ActivitySemantic proximity
Ca 2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2Semantic proximity
Genetically and pharmacologically limiting RyR2 open time prevents neuronal hyperactivity of hippocampal CA1 neurons in brain slices of 5xFAD mice.Semantic proximity
Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake.Semantic proximity
Alzheimer's Presenilin‐1 Mutation Potentiates Inositol 1,4,5‐Trisphosphate‐Mediated Calcium Signaling in <i>Xenopus</i>Semantic proximity
Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.Semantic proximity
FRET-based calcium imaging: a tool for high-throughput/content phenotypic drug screening in Alzheimer disease.Semantic proximity
Select a neighboring publication to make it the new centre.