Article

Alzheimer's Presenilin‐1 Mutation Potentiates Inositol 1,4,5‐Trisphosphate‐Mediated Calcium Signaling in <i>Xenopus</i>

1999-03-01

Abstract excerpt

Abstract : Perturbations in intracellular Ca 2+ signaling may represent one mechanism underlying Alzheimer's disease (AD). The presenilin‐1 gene ( PS1 ), associated with the majority of early onset familial AD cases, has been implicated in this signaling pathway. Here we used the Xenopus oocyte expression system to investigate in greater detail the role of PS1 in intracellular Ca 2+ signaling pathways. Treatment o...

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Literature Corpus work: 59220317-eb27-5544-a322-f74a50314204
DOI: 10.1111/j.1471-4159.1999.721061.x

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