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Article

FRET-based calcium imaging: a tool for high-throughput/content phenotypic drug screening in Alzheimer disease.

Journal of biomolecular screening - 1 Dec 2013

Honarnejad Kamran, Kirsch Achim K, Daschner Alexander, Szybinska Aleksandra, Kuznicki Jacek, Herms Jochen

Abstract excerpt

Perturbed intracellular store calcium homeostasis is suggested to play a major role in the pathophysiology of Alzheimer disease (AD). A number of mechanisms have been suggested to underlie the impairment of endoplasmic reticulum calcium homeostasis associated with familial AD-linked presenilin 1 mutations (FAD-PS1). Without aiming at specifically targeting any of those pathophysiological mechanisms in particular,...

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PMID: 24221842
DOI: 10.1177/1087057113502672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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