Article
Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake.
Journal of cellular and molecular medicine - 1 Sept 2009
Brunello Lucia, Zampese Enrico, Florean Cristina, Pozzan Tullio, Pizzo Paola, Fasolato Cristina
Abstract excerpt
We have previously shown that familial Alzheimer's disease mutants of presenilin-2 (PS2) and, to a lesser extent, of presenilin-1 (PS1) lower the Ca(2+) concentration of intracellular stores. We here examined the mechanism by which wild-type and mutant PS2 affect store Ca(2+) handling. By using HeLa, SH-SY5Y and MEFs as model cells, and recombinant aequorins as Ca(2+) probes, we show evidence that transient...
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