Article

RNA polymerase loss by nuclear rupture drives <i>LMNA</i> cardiomyopathy

2026-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Localized rupture of the nuclear envelope has recently been reported in various pathologies, including cancer 1,2 , neurodegenerative disease 3–5 , myocardial infarction 6 , as well as dilated cardiomyopathy caused by Lamin A/C gene mutations (LMNA-DCM) 7 . Whether and how nuclear rupture contributes to disease remains unknown. Here, we report that nuclear rupture causes global transcription...

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Literature Corpus work: 72ab7198-0d50-5740-b072-872f25f8e32c
DOI: 10.64898/2026.04.03.716433

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