Article
Cellular internalization of cytolethal distending toxin: a new end to a known pathway.
Cellular microbiology - 1 Jul 2005
Guerra Lina, Teter Ken, Lilley Brendan N, Stenerlöw Bo, Holmes Randall K, Ploegh Hidde L, Sandvig Kirsten, Thelestam Monica, Frisan Teresa
Abstract excerpt
The cytolethal distending toxins (CDTs) are unique in their ability to induce DNA damage, activate checkpoint responses and cause cell cycle arrest or apoptosis in intoxicated cells. However, little is known about their cellular internalization pathway. We demonstrate that binding of the Haemophilus ducreyi CDT (HdCDT) on the plasma membrane of sensitive cells was abolished by cholesterol extraction with...
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