Article

Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Reprogramming of Aortic Valve Cells Through STAT5

2022-08-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Calcific aortic valve disease (CAVD) is the pathological remodeling of valve leaflets. The initial steps in valve leaflet osteogenic reprogramming are not fully understood. As telomerase reverse transcriptase (TERT) overexpression primes mesenchymal stem cells to differentiate into osteoblasts, we investigated whether TERT contributes to the osteogenic reprogramming of valve...

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Literature Corpus work: c9188e37-5e91-53f6-8aa5-fd7076aacbcf
DOI: 10.1101/2022.08.23.504425

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