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Article

Advances in single-cell transcriptomics: unraveling the pathogenesis of calcific aortic valve disease.

Cardiovascular research - 14 Feb 2026

Qin Zihan, Bäck Magnus

Abstract excerpt

Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of calcified aortic valve disease (CAVD) by enabling the dissection of cellular heterogeneity, lineage differentiation, and intercellular crosstalk at an unprecedented resolution. It revealed original vistas into the mechanisms of CAVD and novel putative therapeutic targets. This review provides a narrative state-of-the-art overview of scRNA-seq...

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PMID: 41264422
DOI: 10.1093/cvr/cvaf255

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