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Article

MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway.

Scientific reports - 18 Aug 2017

Xu Rongjian, Zhao Min, Yang Yun, Huang Zhuo, Shi Chunying, Hou Xianglin, Zhao Yannan, Chen Bing, Xiao Zhifeng, Liu Jianzhou, Miao Qi, Dai Jianwu

Abstract excerpt

Calcific aortic valve disease (CAVD) is the most common heart valve disorder, yet its mechanism remains poorly understood. Valve interstitial cells (VICs) are the prevalent cells in aortic valve and their osteogenic differentiation may be responsible for calcific nodule formation in CAVD pathogenesis. Emerging evidence shows microRNA (miRNA, or miR) can function as important regulators of many pathological...

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Identifiers

PMID: 28821833
DOI: 10.1038/s41598-017-09390-z
PMCID: PMC5562804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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