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Article

Lumican promotes calcific aortic valve disease through H3 histone lactylation

19 Jun 2024

Abstract excerpt

BACKGROUND AND AIMS: Valve interstitial cells (VICs) undergo a transition to intermediate state cells before ultimately transforming into the osteogenic cell population, which is a pivotal cellular process in calcific aortic valve disease (CAVD). Herein, this study successfully delineated the stages of VIC osteogenic transformation and elucidated a novel key regulatory role of lumican (LUM) in this process....

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PMID: 38976370
DOI: 10.1093/eurheartj/ehae407

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