Article

Immortalization of human valve interstitial cells: an <i>in vitro</i> tool for studying fibro-calcific aortic valve degeneration

2024-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Human primary valve interstitial cells (VIC) are essential for studying the detrimental fibrocalcification processes typical of aortic valve degeneration. However, their limited lifespan poses a significant challenge. To address this, we immortalized VICs to extend their lifespan and facilitate genetic manipulation, enabling the study of dysregulated molecular and cellular pathways in this patho...

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Literature Corpus work: 0c080420-72d8-528c-bbc6-0703b3d8fc59
DOI: 10.1101/2024.09.26.615125

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