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Article

Non-Canonical TERT Activity Initiates Osteogenesis in Calcific Aortic Valve Disease

21 Jan 2025

Abstract excerpt

BACKGROUND: Calcific aortic valve disease is the pathological remodeling of valve leaflets. The initial steps in valve leaflet osteogenic reprogramming are not fully understood. As TERT (telomerase reverse transcriptase) overexpression primes mesenchymal stem cells to differentiate into osteoblasts, we investigated whether TERT contributes to the osteogenic reprogramming of valve interstitial cells. METHODS:...

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PMID: 39835393
DOI: 10.1161/circresaha.122.321889

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