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IL-1-conferred gene expression pattern in ERα <sup>+</sup> BCa and AR <sup>+</sup> PCa cells is intrinsic to ERα <sup>−</sup> BCa and AR <sup>−</sup> PCa cells and promotes cell survival

2019-09-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Breast (BCa) and prostate (PCa) cancers are hormone receptor (HR)-driven cancers. Thus, BCa and PCa patients are given therapies that reduce hormone levels or directly blocks HR activity; but most patients eventually develop treatment resistance. We have previously reported that interleukin-1 (IL-1) inflammatory cytokine downregulates ERα and AR mRNA in HR-positive (HR +...

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Literature Corpus work
c8e57f0d-f73d-5067-a0c7-29974b1ce936
DOI
10.1101/773978
Open publication

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IL-1-conferred gene expression pattern in ERα <sup>+</sup> BCa and AR <sup>+</sup> PCa cells is intrinsic to ERα <sup>−</sup> BCa and AR <sup>−</sup> PCa cells and promotes cell survivalDOI 10.1101/773978
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