Article

An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer

2024-11-25

Abstract excerpt

T cells are generally sparse in hormone receptor-positive (HR+) breast cancer, potentially due to limited antigen presentation, but the driving mechanisms of low T cell abundance remains unclear. Therefore, we defined and investigated programs (‘gene modules’), related to estrogen receptor signaling (ERS) and immune signaling using bulk and single-cell transcriptome and multiplexed immunofluorescence of breast can...

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Literature Corpus work: 6e6f41f9-3e61-5854-b344-8562d209e551
DOI: 10.1101/2024.11.23.619172

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