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Integrated proteomics and transcriptomics analysis reveals key regulatory genes between ER-positive/PR-positive and ER-positive/PR-negative breast cancer

1 Jul 2025

Abstract excerpt

PURPOSE: Hormone receptor-positive breast cancer is characterized by the expression of estrogen receptor (ER) or progesterone receptor (PR), it is generally associated with less aggressive clinical features and more favorable prognostic outcomes, primarily due to the effectiveness of endocrine therapy. However, the loss of PR expression has been correlated with endocrine resistance and poorer prognosis. To date,...

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PMID: 40597935
DOI: 10.1186/s12885-025-14451-y

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