Article

Constitutively Active Androgen Receptor Supports the Metastatic Phenotype of Endocrine-Resistant Hormone Receptor-Positive Breast Cancer

2020-04-16

Abstract excerpt

<h4>Background: </h4> Hormone receptor positive (HR+) breast cancer (BCa) is the most frequently diagnosed subtype. Acquired and intrinsic resistance to conventional endocrine therapy (ET) commonly occurs and prompts incurable metastatic disease. Hence, ET-resistant (ET-R) HR+ BCa presents a therapeutic challenge. Previous studies show elevated androgen receptor (AR) that supports resistance to ET tamoxifen and co...

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Literature Corpus work: baa08ac8-48d3-5fe2-bbe3-726f108f7a9b
DOI: 10.21203/rs.3.rs-21027/v1

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