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IL-1-conferred gene expression pattern in ERα+ BCa and AR+ PCa cells is intrinsic to ERα- BCa and AR- PCa cells and promotes cell survival

2020-01-13

Abstract excerpt

<title>Abstract</title> <p>Background: Breast (BCa) and prostate (PCa) cancers are hormone receptor (HR)-driven cancers. Thus, BCa and PCa patients are given therapies that reduce hormone levels or directly block HR activity; but most patients eventually develop treatment resistance. We have previously reported that interleukin-1 (IL-1) inflammatory cytokine downregulates ERα and AR mRNA in HR-positive (HR+) BCa...

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Literature Corpus work
e5adc2c2-1b11-50f8-acd8-b0188fcf41e0
DOI
10.21203/rs.2.14924/v4
Open publication

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IL-1-conferred gene expression pattern in ERα+ BCa and AR+ PCa cells is intrinsic to ERα- BCa and AR- PCa cells and promotes cell survivalDOI 10.21203/rs.2.14924/v4
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