Article
Identification of an IL-1-induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR- PCa cells.
The Prostate - 1 Jun 2018
Thomas-Jardin Shayna E, Kanchwala Mohammed S, Jacob Joan, Merchant Sana, Meade Rachel K, Gahnim Nagham M, Nawas Afshan F, Xing Chao, Delk Nikki A
Abstract excerpt
BACKGROUND: In immunosurveillance, bone-derived immune cells infiltrate the tumor and secrete inflammatory cytokines to destroy cancer cells. However, cancer cells have evolved mechanisms to usurp inflammatory cytokines to promote tumor progression. In particular, the inflammatory cytokine, interleukin-1 (IL-1), is elevated in prostate cancer (PCa) patient tissue and serum, and promotes PCa bone metastasis. IL-1...
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