Article

Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activity

2025-08-01

Abstract excerpt

The DNA-incorporating nucleoside analogs azacytidine (AZA) and decitabine (DEC) have clinical efficacy in blood cancers, yet the precise mechanism by which these agents kill cancer cells has remained unresolved -- specifically, whether their anti-tumor activity arises from conventional DNA damage or DNA hypomethylation via DNA methyltransferase 1 (DNMT1) inhibition. This incomplete mechanistic understanding has li...

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Literature Corpus work: c8dd79ea-b5ed-549f-a58d-df09da9c0890
DOI: 10.1101/2025.07.29.664810

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