Article

Epigenetic anti-cancer treatment with a stabilized carbocyclic Decitabine analogue

2022-01-22

Abstract excerpt

5-Aza-2’-deoxycytidine (Decitabine, AzadC) is a nucleoside analogue, which is in clinical use to treat patients with myelodysplastic syndrome or acute myeloid leukemia. Its mode of action is unusual because the compound is one of the few drugs that act at the epigenetic level of the genetic code. AzadC is incorporated as an antimetabolite into the genome and creates covalent, inhibitory links to DNA methyltransfer...

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Literature Corpus work: 6edccf89-8bb0-5225-a4bd-be726b5f47fa
DOI: 10.1101/2022.01.19.476908

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