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DNA Methyltransferase Inhibitors and their Therapeutic Potential

29 Nov 2018

Abstract excerpt

Aberrant DNA methylation at the 5-position of cytosine, catalyzed by DNA methyltransferases (DNMTs), is associated with not only various cancers by silencing of tumor suppressor genes but also other diseases. The DNMTs, especially the DNMT1, DNMT3A and DNMT3B, are often overexpressed in various cancer tissues and cell lines. DNMTs are important epigenetic targets for drug development since the DNA methylation is...

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PMID: 30465505
DOI: 10.2174/1568026619666181120150122

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